An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a pluronic lecithin organogel. Geometrically, incorporate the remaining drug into the base and thoroughly mix. Plo gels have already gained acceptance as the transdermal vehicle of choice for a variety of drugs including diclofenac, ibuprofen, ketamine, progesterone and testosterone. Lecithin organogels as a potential phospholipidstructured system for topical drug delivery.
The network component of a hydrogel is usually a polymer network. Stabilization and release effects of pluronic f127 in protein. Transdermal testosterone gels are available and popular among both patients. The objective of the study was to formulate the pluronic lecithin organogel plo containing 5asa and evaluate its woundhealing ability in a full thickness excision wound rat model. Pluronic lecithin organogel plo is made with pluronic gel combined with a. All previous studies of transdermal methimazole in cats have used pluronic lecithin organogel plo gel as the vehicle, 24, 25, 29, 39 however, methimazole is a lipophilic drug, and plo.
Ketoprofen 5% in pluronic lecithin organogel piroxicam 0. From the results of skin compatibility studies it was revealed that topical use of lo is safe55, 61. Pharmaceutical technology laboratory, drug sciences department, faculty of pharmacy, university of porto, portugal. Main features and their applications in topical and transdermal administration of drugs hugo almeida, maria helena amaral, paulo lobao, jose manuel sousa lobo. Topical administration of psychotropic medications in. Plo stands for pluronic lecithin organogel, a mixture of oil and water that thickens to form a gel. Pluronic lecithin organogel is mainly composed of pluronic f127, soy lecithin, and ippipm. The efficacy and safety of a novel lipophilic formulation. Pluronic lecithin organogel plo is a synthetic compound developed in the 1990s as a transdermal 3,4,5drug delivery substrate. Plo gel is similar to the system used in the testosterone. For the past decade, lecithin and pluronic lecithin organogel plo gel have been. Patel institute of pharmaceutical education and research, shirpur, maharashtra, india. Pen travan was designed to maintain the lipo somal technology of plo while removing the cosmetic and preparation drawbacks. The efficacy and safety of a novel lipophilic formulation of.
May 21, 20 the pluronic f127 solution may be prepared by mixing 0. Find patient medical information for plo gel premium lecithin organogel base transdermal on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The aim of this study is to characterize the percutaneous absorption of 2 ketoprofen formulations ketoprofen 10% in pluronic lecithin organogel plo and ketoprofen 10% in lipoderm, referred to. Formulation and clinical evaluation of silymarin pluronic. Transdermal lidocaine and ketamine for neuropathic pain. Menthol eutectic ointment 2% testosterone for men nsaid gel. Pcca science professional compounding centers of america. Compounding pharmacists are advertising the vehicle,as well as their compounding services, and a large number of drugs have already been incorporated within. They were admitted to the northwestern university general clinical research center twice, being randomly assigned to receive either 1ml of morphine compounded at 10mgml in pluronic lecithin organogel. Lecithin is biocompatible in nature and is a component of cell membranes. Evaluation of transdermal morphine and fentanyl pluronic. Jan 21, 2010 they were admitted to the northwestern university general clinical research center twice, being randomly assigned to receive either 1ml of morphine compounded at 10mgml in pluronic lecithin organogel plo base applied to the wrist and 1ml of normal saline administered subcutaneously, or 1ml of topical drugfree plo base and 1ml of. Td plo ultramax gel transderma pharmaceuticals inc. Dec 20, 2011 the pluronic f127 solution may be prepared by mixing 0.
Pluronic lecithin organogels plo gels are lecithinbased organogels widely used in. Plo has been shown in vivo and in vitro to modulate the release and permeation of drugs applied transdermally. Gralla gel is often packaged in unitdose topical syringes for easy dosing. Lecithin organogel lo is one class of promising vehicles for the delivery of a wide variety of bioactive agents through the skin. It provides new perspective for topical delivery of antiaging agents to treat the signs and symptoms of skin aging. Selegiline hydrochloride 10 mgml in pluronic lecithin organogel. To this gel is added a penetration enhancer to make plo, a commonly used pharmacy name for pluronic lecithin organogel, which consists of poloxamer pluronic gel with added lecithin and isopropyl. Us patent application for phase stable lecithin organogel. Preparation and evaluation of tubular micelles of pluronic lecithin. Our goal is to provide the most effective, innovative, and functional products for the compounding industry. For the past decade, lecithin and pluronic lecithin organogel plo gel have been intensively studied for the formulation of controlled release which shows low skin irritation and increases drug permeation. Mix the nifedipine with the ethoxy diglycol to form a smooth paste. The adhesive side of the testoderm testosterone transdermal tts system should be placed on a clean, dry area of skin on the arm, back or upper buttocks immediately upon removal from the protective pouch. These systems are currently of interest to the pharmaceutical.
A lecithin organogel composition used to deliver pharmaceutical products. In vitro percutaneous absorption of ketoprofen and testosterone. Pluronic lecithin organogel plo is a vehicle used in the compounding of transdermal preparations. Boost testosterone naturally with these 5 proven ways. Pluronic lecithin organogel plo gel as a carrier plo gel looks and feels like a cream but is actually a gel. Pluronic lecithin organogel how is pluronic lecithin organogel abbreviated. Us20090017120a1 phase stable lecithin organogel composition. The formulation has referred to as pluronic lecithin organogels.
Development and evaluation of pluronic lecithin organogel. Aetna compounded drug products coverage policy nonmedicare prescription drug plan p urpose. In vitro percutaneous absorption of ketoprofen and testosterone ncbi. Pluronic lecithin organogel is an organic mixture that supports mold growth.
Such a characteristic immediately suits it to protein drug stabilization and release effects of pluronic f127 in protein drug delivery jeremy. Usually prepared in a pluronic lecithin organogel plo base, gralla gel consists of haloperidol, diphenhydramine, metoclopramide, and dexamethasone. Pluronic lecithin organogel plo is a new transdermal drug delivery system into which drugs can be incorporated. Plo gel premium lecithin organogel base transdermal.
Plo gel is similar to the system used in the testosterone preparation androgel. Recent reports have also suggested the incorporation of synthetic polymers e. Isopropyl palmitate solution 20 g pluronic f127 20%. The objective of this study was to evaluate five commercial readytouse transdermal vehicles phytobase, lipovan, pentravan, pentravan plus and pluronic lecithin organogel plo, for the compounding of three antiemetic drugs ondansetron, dexamethasone and aprepitant and their administration in combination to treat chemotherapyinduced nausea and vomiting cinv at the hospital. The most common transdermal vehicle is pluronic lecithin organogel plo. With some cats, giving an oral medication can be challenging and alternatives have been sought. Transderma plo pluronic lecithin organogel ultramax gel answers the need for readytouse vehicles to incorporate higher percentages of active drugs, without disturbing the elegant nature or the efficacy of the gel. Controlled release of testosterone by polymerpolymer. International journal of pharmaceutical compounding. This base is designed for the transdermal delivery of lipophilic apis such as nsaids and bioidentical hormones. Testoderm testosterone transdermal tts one system is applied at about the same time each day. Combining the aqueous phase pluronic gel with the lecithin oil base creates an emulsion that holds together due to the surfactant qualities of the pluronic gel and the viscosity of that gel at room temperature.
Plo is usually composed of isopropyl palmitate, soy lecithin, water, and pluronic f127. Plo gel may include isopropyl palmitate, soy lecithin, water, and pluronic f127. Whereas transdermal patches may have several limitations such as fluid. In the present work, pluronic lecithin organogel was prepared for. The purpose of this policy is to define coverage criteria for compounded drug products. Organogels, hydrogels and bigels as transdermal delivery. Lecithin organogels as a potential phospholipidstructured. Selegiline hydrochloride in pluronic lecithin organogel has been used in the treatment of parkinsons disease and other conditions of cognitive impairment. Pluronic lecithin organogel definition of pluronic lecithin. Methimazole is commonly used for the medical management of hyperthyroidism in cats. Antimicrobial preservatives are often added to pluronic lecithin organogel in order to supplement intrinsic antimicrobial activity. An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a pluronic lecithin organogel and pentravan. In recent years, pf127, and later, pluronic lecithin organogels plo, have attracted particular interest in the design of dermal and transdermal delivery systems with a view to promoting. These pluronic containing lecithin organogels have been termed as pluronic.
Evaluation of pentravan, pentravan plus, phytobase. Pandey m1, belgamwar v, gattani s, surana s, tekade a. Rx testosterone 20 mgml in pluronic lecithin organogel testosterone 2 g propylene glycol 20 ml lecithin. Pluronic lecithin organogel gel looks and feels like a cream but is actually a gel. Combining the aqueous phase pluronic gel with the lecithin oil base creates an emulsion that holds together due to the surfactant qualities of the pluronic. Pluronic lecithin organogel plo it consists of a pluronic poloxamer f127 gel usually 20% or 30% concentration mixed at a ratio of approximately 1. Isopropyl palmitate solution 20 g pluronic f127 20% gelqs 100 ml procedure. To this gel is added a penetration enhancer to make plo, a commonly used pharmacy name for pluronic lecithin organogel, which consists of poloxamer pluronic gel with added lecithin and isopropyl palmitate or isopropyl myristate. Brand hair grows everywhere on our body except on the palms of our hands and the soles of our feet. Upon a prescription order, compounding pharmacists can use testosterone usp. One proven solution for hospice patients is a preparation known as gralla gel.
Thus, organogels are promising vehicles for cutaneous administration 26,27. This transdermal weed patch wont send you to the moon. Plo gel or pluronic lecithin organogel is a transdermal carrier used by compounding pharmacists to deliver nsaids,narcotics and other drugs through the skin when other routes of administration are not viable. Pluronic lecithin organogel how is pluronic lecithin. Formulation of silymarin into pluronic lecithin organogel plo basis for topical skin delivery is the main aim of this work. A hydrogel in which the network component is a colloidal network may be referred to as an aquagel. Formulation and evaluation of lecithin organogel for topical. Pluronic f127 is one such surfactant with an additional property in aqueous solution. Pluronic lecithin organogel as a topical drug delivery system 39 topical drug treatment aims at providing high concentration of the drug at the site of application so as to avoid systemic adverse effects associated with oral administration of drug. Dec 30, 2016 read evaluation of pentravan, pentravan plus, phytobase, lipovan and pluronic lecithin organogel for the transdermal administration of antiemetic drugs to treat chemotherapyinduced nausea and vomiting at the hospital, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your. Pluronic lecithin organogels plo gels are lecithinbased organogels widely. Pluronic lecithin organogel definition of pluronic. Pluronic lecithin organogel as a topical drug delivery system.
Lecithin organogel, fluconazole, permeation study, antifungal activity, topical delivery. Organogel plus is specially formulated to allow compounding of higher concentrations of actives available in. Pluronic f127 is a polymeric surfactant which allows the formation of drug micelles in a gel matrix. Jan 11, 2016 in the present study, pluronic lecithin organogel plo of diltiazem hydrochloride dzh was developed by taking different ratios of organic phase to aqueous phase 1. Evaluation of transdermal drug permeation as modulated by. Kits of 500 ml premixed cream of 500 g organogel plus is a liposomal base pluronic lecithin organogel or plo gel that is used for preparing a wide range of topical formulations. Pentravan cream abstract an in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a pluronic lecithin organogel and pentravan cream. For both compounds, a greater rate and extent of absorption was found from the pentravan formulation than from the pluronic lecithin organogel formulation. Sep 28, 2011 all previous studies of transdermal methimazole in cats have used pluronic lecithin organogel plo gel as the vehicle, 24, 25, 29, 39 however, methimazole is a lipophilic drug, and plo gel might not be the most suitable vehicle for a lipid soluble drug. The above recommended concentrations are for transdermal application. A promising avenue is the transdermal application of methimazole in a pleuronic lecithin organogel. Plo gel looks and feels like a cream but is actually a gel. In that spirit, we have committed significant resources to the study and validation of our technology.
Pluronic lecithin organogels plo gels are lecithinbased organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. Td plo gel represent a readytouse plo gel premium lecithin organogel. The pluronic f127 solution may be prepared by mixing 0. Jul 02, 2015 by sayer ji originally posted on boosting testosterone has become all the rage today, but unless you activate your bodys innate ability to do it naturally you will have to face the possibility of serious side effects. Request pdf evaluation of pentravan, pentravan plus, phytobase, lipovan and pluronic lecithin organogel for the transdermal administration of antiemetic drugs to treat chemotherapy. Controlled release of testosterone by polymerpolymer interaction. Prepare a paste of the testosterone and the propylene glycol. An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a pluronic lecithin organogel and pentravan cream. Pluronics into lecithin organogels as cosurfactants and stabilizers that makes gelation feasible with lecithin of a relative lower purity. Six different plo formulations were prepared containing various pluronic to lecithin ratios using two cosolvent systems of ethyl alcohol and dimethyl sulfoxide.
Pdf in vitro percutaneous absorption of ketoprofen and. The purpose of the present study was to develop and investigate the suitability of microemulsion based lecithin organogel formulations for topical delivery of fluconazole in order to bypass its gastrointestinal adverse effects. Those of you who use transdermal gels like dmso or other carriers might want to check pluronic lecithin organogel plo gel out. Pluronic lecithin organogel as a topical drug delivery system 39 topical drug treatment aims at providing high concentration of the drug at the site of application so as to avoid systemic adverse effects. Phlojel or pluronic lecithin organogel is a transdermal carrier used by compounding pharmacists to deliver nsaids,narcotics and other drugs through the skin when other routes of administration are not viable. Each formulation was applied to ex vivo human trunk skin from three skin donors on triplicate sections mounted onto franz diffusion cells. Pharmacist compounding of medication is the combination of the art and science of pharmacy. Pluronic lecithin organogel of 5aminosalicylic acid for. The lipoilpoloxamer combination is known colloquially as plo or pluronic lecithin organogel. When combined with a therapeutic agent, plo forms drug micelles in a. Find patient medical information for lecithin organogel on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The transdermal patches use whats called an extended release pluronic lecithin organogel plo delivery system. In vitro percutaneous absorption of ketoprofen and.
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